Durable response to CAR T is associated with elevated activation and clonotypic expansion of the cytotoxic native T cell repertoire

Durable response to CAR T is associated with elevated activation and clonotypic expansion of the cytotoxic native T cell repertoire

Abstract While Chimeric Antigen Receptor (CAR) T cell therapy may result in durable remissions in recurrent large B cell lymphoma, persistence is limited and the mechanisms underlying long-term response are not fully elucidated. Using longitudinal single-cell immunoprofiling, here we compare the imm...

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Main Authors: Giulia Cheloni, Dimitra Karagkouni, Yered Pita-Juarez, Daniela Torres, Eleni Kanata, Jessica Liegel, Zachary Avigan, Isabella Saldarriaga, Georges Chedid, Kathrine Rallis, Brodie Miles, Gayatri Tiwari, Jenny Kim, Mike Mattie, Jacalyn Rosenblatt, Ioannis S. Vlachos, David Avigan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59904-x
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https://doi.org/10.1038/s41467-025-59904-x

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