The Role of APOA-I in Alzheimer’s Disease: Bridging Peripheral Tissues and the Central Nervous System

The Role of APOA-I in Alzheimer’s Disease: Bridging Peripheral Tissues and the Central Nervous System

Lipid metabolism disorders represent a significant risk factor for the pathogenesis of Alzheimer’s disease (AD). Apolipoprotein E (APOE) has been regarded as a pivotal regulator of lipid homeostasis in the central nervous system (CNS), with polymorphic alleles identified as genetic risk factors for...

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Bibliographic Details
Main Authors: Guanfeng Xie, Gege Jiang, Liqin Huang, Shangqi Sun, Yuwei Wan, Fang Li, Bingjie Wu, Ying Zhang, Xiaoyi Li, Bingwan Xiong, Jing Xiong
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
Alzheimer’s disease
apolipoprotein A1
amyloid beta peptide
lipid metabolism
high-density lipoprotein
Online Access:https://www.mdpi.com/1424-8247/18/6/790
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