Ferritin-Based HA DNA Vaccine Outperforms Conventional Designs in Inducing Protective Immunity Against Seasonal Influenza

Ferritin-Based HA DNA Vaccine Outperforms Conventional Designs in Inducing Protective Immunity Against Seasonal Influenza

<b>Background</b>: Influenza remains a persistent public health challenge due to antigenic drift and shift, necessitating vaccines capable of eliciting broad and durable immunity. Hemagglutinin (HA) antigen serves as the critical target for eliciting protective immune responses against i...

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Main Authors: Hongzhe Lin, Yuxuan Jiang, Yan Li, Yiwei Zhong, Mingyue Chen, Weiyu Jiang, Rong Xiang, Najing Cao, Lei Sun, Xuanyi Wang, Lu Lu, Qiao Wang, Guangyue Han, Duan Ma, Bin Wang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Vaccines
Subjects:
DNA vaccine
influenza
hemagglutinin (HA) antigen
immunogenicity
ferritin-based vaccine
Online Access:https://www.mdpi.com/2076-393X/13/7/745
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