Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model

Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model

Abstract Impaired interaction of fibroblasts with pneumocytes contributes to the progression of chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is associated with IPF. Here we analyzed the interaction of primary fibroblasts and alveolar type 2 (AT2) pneumocytes in...

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Main Authors: Yiwen Yao, Felix Ritzmann, Sarah Miethe, Kathrin Kattler-Lackes, Betül Colakoglu, Christian Herr, Andreas Kamyschnikow, Michelle Brand, Holger Garn, Daniela Yildiz, Frank Langer, Robert Bals, Christoph Beisswenger
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Medicine
Subjects:
Organoid
Pneumocyte
Fibroblast
STAT3
IPF
Online Access:https://doi.org/10.1186/s10020-024-00990-w
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https://doi.org/10.1186/s10020-024-00990-w

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