Effects of sacubitril/valsartan on hypertensive heart disease: the REVERSE-LVH randomized phase 2 trial

Effects of sacubitril/valsartan on hypertensive heart disease: the REVERSE-LVH randomized phase 2 trial

Abstract Diffuse interstitial fibrosis is associated with adverse outcomes in hypertensive heart disease and may be reversible. Sacubitril/valsartan could offer greater anti-fibrotic effects than valsartan alone. In the REVERSE-LVH phase 2 open-labelled trial (clinicaltrials.gov NCT: 03553810; funde...

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Main Authors: Vivian Lee, Mayank Dalakoti, Qishi Zheng, Desiree-Faye Toh, Redha Boubertakh, Jennifer A. Bryant, Tar-Choon Aw, Chi-Hang Lee, A. Mark Richards, Javed Butler, Javier Díez, Roger Foo, Stuart A. Cook, Carolyn SP Lam, Thu-Thao Le, Calvin WL Chin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62203-0
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https://doi.org/10.1038/s41467-025-62203-0

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