Ouabain Counteracts Retinal Ganglion Cell Death Through Modulation of BDNF and IL-1 Signaling Pathways

Ouabain Counteracts Retinal Ganglion Cell Death Through Modulation of BDNF and IL-1 Signaling Pathways

<b>Background:</b> Ouabain is a steroid hormone that binds to the sodium pump (Na<sup>+</sup>, K<sup>+</sup>-ATPase) at physiological (nanomolar) concentrations, activating different signaling pathways. This interaction has been shown to prevent the axotomy-induce...

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Main Authors: Amanda Candida da Rocha Oliveira, Camila Saggioro Figueiredo, Ícaro Raony, Juliana Salles Von-Held-Ventura, Marcelo Gomes Granja, Thalita Mázala-de-Oliveira, Vinícius Henrique Pedrosa-Soares, Aline Araujo dos Santos, Elizabeth Giestal-de-Araujo
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Brain Sciences
Subjects:
brain-derived neurotrophic factor
cytokine
growth factor
steroid hormone
interleukin-1β
matrix metalloproteinase-9
Online Access:https://www.mdpi.com/2076-3425/15/2/123
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