Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro

Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro

Abstract Background Tumor-derived small extracellular vesicles (sEVs) have been implicated in changes of the blood–brain barrier (BBB) during pre-metastatic niche formation. Although it was postulated that sEVs can traverse the highly restrictive BBB via transcytosis—data mostly based on the indirec...

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Bibliographic Details
Main Authors: Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Fluids and Barriers of the CNS
Subjects:
Small extracellular vesicles
Prostate cancer
Biological barriers
Blood–brain barrier
Inflammatory cytokines
Online Access:https://doi.org/10.1186/s12987-025-00680-7
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https://doi.org/10.1186/s12987-025-00680-7

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