Microglial Transient Receptor Potential Melastatin 2 Deficiency Accelerates Seizure Development via Increasing AMPAR‐Mediated Neuronal Excitability

Microglial Transient Receptor Potential Melastatin 2 Deficiency Accelerates Seizure Development via Increasing AMPAR‐Mediated Neuronal Excitability

ABSTRACT Epilepsy is one of the most common neurological disorders, characterized by the enhancement of neural excitability from a neurocentric perspective. Emerging evidence indicates that microglia play a pivotal role in the pathogenesis of epilepsy through complex and various mechanisms that is s...

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Main Authors: Yingwei Xu, Luyu Ye, Zhisheng Li, Yi Zhang, Ning Hua, Xiaojun Wang, Wangjialu Lu, Jing Xi, Liying Chen, Cenglin Xu, Jiajia Fang, Jianhong Luo, Linhua Jiang, Feng Han, Zhong Chen, Yi Wang, Wei Yang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:MedComm
Subjects:
TRPM2 channel
seizure
microglia
AMPAR
neuron
Online Access:https://doi.org/10.1002/mco2.70271
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https://doi.org/10.1002/mco2.70271

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