The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells.

The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells.

Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host membrane fusion and virus entry. Interfering with HS-herpesvirus interaction...

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Main Authors: Dipanwita Mitra, Mohammad H Hasan, John T Bates, Michael A Bierdeman, Dallas R Ederer, Rinkuben C Parmar, Lauren A Fassero, Quntao Liang, Hong Qiu, Vaibhav Tiwari, Fuming Zhang, Robert J Linhardt, Joshua S Sharp, Lianchun Wang, Ritesh Tandon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009803&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009803&type=printable

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