Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infection

Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infection

Summary: Long-lived humoral memory is key to durable immunity against pathogens yet remains challenging to define due to heterogeneity among antigen-reactive B cells. We addressed this gap through longitudinal sampling over the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) m...

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Main Authors: Lela Kardava, James Lim, Clarisa M. Buckner, Felipe Lopes de Assis, Xiaozhen Zhang, Wei Wang, Mattie L. Melnyk, Omar El Merhebi, Krittin Trihemasava, I-Ting Teng, Robin Carroll, Yogita Jethmalani, Mike Castro, Bob C. Lin, Lauren H. Praiss, Catherine A. Seamon, Peter D. Kwong, Richard A. Koup, Leonid Serebryannyy, David C. Nickle, Tae-Wook Chun, Susan Moir
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003286
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