The PKM2 activator TEPP‐46 suppresses cellular senescence in hydrogen peroxide‐induced proximal tubular cells and kidney fibrosis in CD‐1db/db mice

The PKM2 activator TEPP‐46 suppresses cellular senescence in hydrogen peroxide‐induced proximal tubular cells and kidney fibrosis in CD‐1db/db mice

ABSTRACT Aim/Introduction Senescence is a key driver of age‐related kidney dysfunction, including diabetic kidney disease. Oxidative stress activates cellular senescence, induces abnormal glycolysis, and is associated with pyruvate kinase muscle isoform 2 (PKM2) dysfunction; however, the mechanisms...

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Main Authors: Shin‐ichiro Ishihara, Md. Imrul Kayes, Hirofumi Makino, Hiroaki Matsuda, Asako Kumagai, Yoshihiro Hayashi, Sara Amelia Ferdaus, Emi Kawakita, Daisuke Koya, Keizo Kanasaki
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of Diabetes Investigation
Subjects:
DKD
PKM2
Senescence
Online Access:https://doi.org/10.1111/jdi.14397
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https://doi.org/10.1111/jdi.14397

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