CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection

CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection

Immune overactivation is a hallmark of chronic HIV infection, which is critical to HIV pathogenesis and disease progression. The imbalance of helper T cell (Th) differentiation and subsequent cytokine dysregulation are generally considered to be the major drivers of excessive activation and inflamma...

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Main Authors: Xinyue Wang, Yuqing Wei, Zhijiao He, Di Wang, Leidan Zhang, Juan Du, Mengyuan Zhang, Meiqing Jiang, Na Chen, Meiju Deng, Bei Li, Chuan Song, Danying Chen, Huan Liu, Jiang Xiao, Hongyuan Liang, Hongxin Zhao, Yaxian Kong
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
HIV
CD4+ T cells
CD70
Th differentiation
poor immune reconstitution
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2271068
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https://www.tandfonline.com/doi/10.1080/22221751.2023.2271068

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