AMHY and sex determination in egg-laying mammals

AMHY and sex determination in egg-laying mammals

Abstract Background Egg-laying mammals (monotremes) evolved multiple sex chromosomes independently of therian mammals and lack the sex-determining gene SRY. The Y-localized anti-Müllerian hormone gene (AMHY) is the candidate sex-determination gene in monotremes. Here, we describe the evolution of mo...

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Main Authors: Linda Shearwin-Whyatt, Jane Fenelon, Hongshi Yu, Andrew Major, Zhipeng Qu, Yang Zhou, Keith Shearwin, James Galbraith, Alexander Stuart, David Adelson, Guojie Zhang, Michael Pyne, Stephen Johnston, Craig Smith, Marilyn Renfree, Frank Grützner
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Biology
Subjects:
Anti-Müllerian hormone (AMH)
Monotreme
Sex determination
Echidna
Platypus
Online Access:https://doi.org/10.1186/s13059-025-03546-1
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https://doi.org/10.1186/s13059-025-03546-1

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