Lysosome and plasma membrane Piezo channels of Trypanosoma cruzi are essential for proliferation, differentiation and infectivity.

Trypanosoma cruzi, the causative agent of Chagas disease, is a parasitic protist that affects millions of people worldwide. Currently there are no fully effective drugs or vaccines available. Contact of T. cruzi infective forms with their host cells or with the extracellular matrix increases their i...

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Bibliographic Details
Main Authors: Guozhong Huang, Mayara S Bertolini, Justin Wiedeman, Ronald D Etheridge, Teresa Cruz-Bustos, Roberto Docampo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013105
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