The gold complex auranofin sensitizes platinum resistant epithelial ovarian cancer cells to cisplatin

The gold complex auranofin sensitizes platinum resistant epithelial ovarian cancer cells to cisplatin

Although numerous drugs have been tested to treat ovarian cancer (OC), survival rates remain low as there has been no major improvement from platinum (Pt)–based therapy and there is a high rate of Pt resistance in these tumors. Following several rounds of chemotherapy, OC cells develop Pt-resistance...

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Bibliographic Details
Main Authors: Farah H. Abdalbari, Benjamin N. Forgie, Edith Zorychta, Alicia A. Goyeneche, Abu Shadat M. Noman, Carlos M. Telleria
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Ovarian cancer
Auranofin
Cisplatin
Reactive oxygen species
Intrinsic apoptosis
DNA damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825000834
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