In silico molecular studies of Phosphinogold(I) thiocarbohydrate complexes: insights into multi-target anticancer mechanisms

In silico molecular studies of Phosphinogold(I) thiocarbohydrate complexes: insights into multi-target anticancer mechanisms

Introduction:This study employed in silico methods to investigate the anticancer potential and mechanisms of twenty novel phosphinogold(I) thiocarbohydrate complexes.Methods:Molecular docking and Prime MM-GBSA screening of seventeen cancer-related protein targets, including Human Double Minute 2 pro...

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Bibliographic Details
Main Authors: Alkhair Adam Khalil Mohamed, Isaac Asiamah, Ghazi Elamin, James Darkwa, Christian K. Adokoh
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Chemistry
Subjects:
anticancer activity
cytotoxicity
MM-GBSA
molecular docking
structure activity relationship
thiocarbohydrate Phosphinogold(I) complexes
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1533026/full
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https://www.frontiersin.org/articles/10.3389/fchem.2025.1533026/full

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