IFITMs exhibit antiviral activity against Chikungunya and Zika virus infection via the alteration of TLRs and RLRs signaling pathways

IFITMs exhibit antiviral activity against Chikungunya and Zika virus infection via the alteration of TLRs and RLRs signaling pathways

Abstract Chikungunya virus (CHIKV) poses a significant challenge as there are currently no targeted antiviral drugs or vaccines to combat this infection. Here, we demonstrate that interferon-induced transmembrane proteins (IFITMs), including IFITM1, IFITM2, and IFITM3, which are interferon-stimulate...

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Main Authors: Nuttamonpat Gumpangseth, Paola Mariela Saba Villarroel, Abibatou Diack, Thanaphon Songhong, Sakda Yainoy, Rodolphe Hamel, Wipaporn Khanom, Phanit Koomhin, Chuchard Punsawad, Anon Srikiatkhachorn, Dorothée Missé, Phoonthawee Saetear, Sineewanlaya Wichit
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Chikungunya virus
Zika virus
IFITMs
Arbovirus
TLRs and RLRs signaling pathways
Online Access:https://doi.org/10.1038/s41598-025-00663-6
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https://doi.org/10.1038/s41598-025-00663-6

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