A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification

A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification

Low-grade inflammation and pathological endochondral ossification are key processes underlying the progression of osteoarthritis, the most prevalent joint disease worldwide. In this study, we employed a multi-faceted approach, integrating publicly available datasets, in silico analyses, in vitro exp...

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Bibliographic Details
Main Authors: Mauricio N. Ferrao Blanco, Raphaelle Lesage, Nicole Kops, Niamh Fahy, Fjodor T. Bekedam, Athina Chavli, Yvonne M. Bastiaansen-Jenniskens, Liesbet Geris, Mark G. Chambers, Andrew A. Pitsillides, Roberto Narcisi, Gerjo J.V.M. van Osch
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Chondrocyte hypertrophy
Inflammation
Kinase inhibitor
Virtual cell
Drug target
Author e-mails
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024169022
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