Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner

Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner

Abstract Advanced colorectal cancer (CRC) continues to present with poor survival and treatment options remain limited. We have shown that increased activin A (activin) expression in the tumor microenvironment (TME) is associated with poor outcome in a cohort of stage III and IV CRC patients. Here,...

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Bibliographic Details
Main Authors: Mark B. Wiley, Jessica Bauer, Valentina Alvarez, Zoe Kolics, Wenxuan Cheng, David N. Church, David J. Kerr, Rachel S. Kerr, Barbara Jung
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Activin A
Digital Spatial profiling
Colorectal Cancer
Tumor microenvironment
Metastasis
Online Access:https://doi.org/10.1038/s41598-025-91853-9
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https://doi.org/10.1038/s41598-025-91853-9

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