LC-MS/MS quantification of omadacycline in human plasma for therapeutic drug monitoring: method development and clinical application
Abstract Omadacycline, a third-generation tetracycline antibiotic, exhibits time-dependent pharmacokinetics. The ratio of the 24-hour area under the concentration-time curve to minimum inhibitory concentration (AUC0−24/MIC) serves as the primary pharmacokinetic/pharmacodynamic (PK/PD) index for omad...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-13396-3 |
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