Club cell-derived brain-derived neurotrophic factor regulates murine airway mechanics and mucin production in response to IL-13 in a sex-dependent manner

IntroductionBrain-derived neurotrophic factor (BDNF) is a neural plasticity molecule that is increasingly recognized for its role in airway pathophysiology, including diseases like asthma. Although many cells in the airway can produce BDNF, our understanding of epithelial-derived BDNF and its role i...

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Bibliographic Details
Main Authors: Amy Fagan, Mariana Sponchiado, Luz Mata, Shanil Amin, J. Ignacio Aguirre, Sreekala Prabhakaran, Leah R. Reznikov
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Physiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1578553/full
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