Overcoming Therapy Resistance in Colorectal Cancer: Targeting the Rac1 Signaling Pathway as a Potential Therapeutic Approach

Overcoming Therapy Resistance in Colorectal Cancer: Targeting the Rac1 Signaling Pathway as a Potential Therapeutic Approach

Colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide and is responsible for numerous deaths. 5-fluorouracil (5-FU) is an effective chemotherapy drug commonly used in the treatment of CRC, either as monotherapy or in combination with other drugs. However, half of CRC...

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Bibliographic Details
Main Authors: Luciano E. Anselmino, Florencia Malizia, Aylén Avila, Nahuel Cesatti Laluce, Macarena Mamberto, Lucía C. Zanotti, Cecilia Farré, Vincent Sauzeau, Mauricio Menacho Márquez
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
colorectal cancer
resistance
small GTPases
Rac1
repositioning
Online Access:https://www.mdpi.com/2073-4409/13/21/1776
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