Cytotoxic, Antioxidant, and Anti-Genotoxic Properties of Combretastatin A4 in Human Peripheral Blood Mononuclear Cells: A Comprehensive In Vitro Study

Cytotoxic, Antioxidant, and Anti-Genotoxic Properties of Combretastatin A4 in Human Peripheral Blood Mononuclear Cells: A Comprehensive In Vitro Study

Despite significant advances in drug discovery and the promising antitumor potential of combretastatin A4 (CA-4), which selectively targets rapidly dividing cancer cells, CA-4’s effects on non-dividing human cells, such as peripheral blood mononuclear cells (PBMCs), remain unclear. The aim of this s...

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Bibliographic Details
Main Authors: Petar Popović, Andrea Pirković, Dijana Topalović, Lada Živković, Milica Marković, Biljana Spremo-Potparević
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
combretastatin A4
PBMC
oxidative stress
genotoxicity
trophoblast
Online Access:https://www.mdpi.com/2218-273X/14/12/1535
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