ProtAlign-ARG: antibiotic resistance gene characterization integrating protein language models and alignment-based scoring

ProtAlign-ARG: antibiotic resistance gene characterization integrating protein language models and alignment-based scoring

Abstract The evolution and spread of antibiotic resistance pose a global health challenge. Whole genome and metagenomic sequencing offer a promising approach to monitoring the spread, but typical alignment-based approaches for antibiotic resistance gene (ARG) detection are inherently limited in the...

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Main Authors: Shafayat Ahmed, Muhit Islam Emon, Nazifa Ahmed Moumi, Lifu Huang, Dawei Zhou, Peter Vikesland, Amy Pruden, Liqing Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
ARG
Protein language model
Deep learning
Protein sequence
Online Access:https://doi.org/10.1038/s41598-025-14545-4
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https://doi.org/10.1038/s41598-025-14545-4

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