JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism

JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism

Objective: Hypothalamic energy sensors, such as AMP-activated protein kinase (AMPK), and stress sensors, such as c-Jun N-terminal kinase 1 (JNK1, also known as MAPK8) modulate whole body energy balance. While the role of AMPK in steroidogenic factor 1 (SF1) neurons of the VMH has been investigated,...

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Main Authors: Iara Fernández-González, Oscar Freire-Agulleiro, Vitor Ferreira, María Silveira-Loureiro, Eva Rial-Pensado, Pablo Garrido-Gil, Gloria Martínez, Patricia Rada, José L. Labandeira-García, Jens Mittag, Ismael González-García, Carlos Diéguez, Rubén Nogueiras, Ángela M. Valverde, Roger J. Davis, Guadalupe Sabio, Olga Barca-Mayo, Miguel López
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular Metabolism
Subjects:
Hypothalamus
SF1
JNK1
BAT
Liver
T3
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000778
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