Vascular and glymphatic dysfunction as drivers of cognitive impairment in Alzheimer's disease: Insights from computational approaches

Vascular and glymphatic dysfunction as drivers of cognitive impairment in Alzheimer's disease: Insights from computational approaches

Alzheimer's disease (AD) is driven by complex interactions between vascular dysfunction, glymphatic system impairment, and neuroinflammation. Vascular aging, characterized by arterial stiffness and reduced cerebral blood flow (CBF), disrupts the pulsatile forces necessary for glymphatic clearan...

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Bibliographic Details
Main Authors: Gehan Fatima, Akm Ashiquzzaman, Sang Seong Kim, Young Ro Kim, Hyuk-Sang Kwon, Euiheon Chung
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Vascular dysfunction
Glymphatic system
Cognitive decline
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000932
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