A computational dynamic systems model for in silico prediction of neural tube closure defects

A computational dynamic systems model for in silico prediction of neural tube closure defects

Neural tube closure is a critical morphogenetic event during early vertebrate development. This complex process is susceptible to perturbation by genetic errors and chemical disruption, which can induce severe neural tube defects (NTDs) such as spina bifida. We built a computational agent-based mode...

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Bibliographic Details
Main Authors: Job H. Berkhout, James A. Glazier, Aldert H. Piersma, Julio M. Belmonte, Juliette Legler, Richard M. Spencer, Thomas B. Knudsen, Harm J. Heusinkveld
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Toxicology
Subjects:
Neural tube closure
Multicellular agent-based model
Computer simulation
Developmental toxicity
In silico
Probabilistic assessment
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X2400063X
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