Multi-Antigen Viral-Vectored Vaccine Protects Against SARS-CoV-2 and Variants in a Lethal hACE2 Transgenic Mouse Model

Multi-Antigen Viral-Vectored Vaccine Protects Against SARS-CoV-2 and Variants in a Lethal hACE2 Transgenic Mouse Model

Widespread and rapidly evolving SARS-CoV-2 posed an unprecedented challenge to vaccine developers. GeoVax has designed a multiantigen SARS-CoV-2 vaccine, designated GEO-CM02 based on a Modified Vaccinia Virus (MVA) vector that expresses spike (S), membrane (M), and envelope (E) antigens. This experi...

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Bibliographic Details
Main Authors: Shannon Stone, Amany Elsharkawy, J. D. Burleson, Mary Hauser, Arban Domi, Pratima Kumari, Zainab Nabi, Janhavi P. Natekar, Maciel Porto, Brian Backstedt, Mark Newman, Sreenivasa Rao Oruganti, Mukesh Kumar
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Vaccines
Subjects:
SARS-CoV-2
COVID-19
MVA-VLP
Online Access:https://www.mdpi.com/2076-393X/13/4/411
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