Repurposing statins for the treatment of larval cestodiases: in silico evaluation of statin-HMG-CoA reductase interactions and assessment of statin effects on a cestode model

Repurposing statins for the treatment of larval cestodiases: in silico evaluation of statin-HMG-CoA reductase interactions and assessment of statin effects on a cestode model

Cestodiases, like echinococcoses and cysticercoses, represent a global health problem. Currently available anthelmintics, as benzimidazoles and praziquantel, have limited effectiveness against these cestodiases, creating a demand for the identification of new and more effective drugs. Here, the pote...

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Main Authors: Marina Monteiro Guedes, Jeferson Camargo de Lima, Jéssica Andrade Paes, María del Pilar Cevasco Contreras, Ana María Celentano, Arnaldo Zaha, Karina Mariante Monteiro, Mara Cecilia Rosenzvit, Henrique Bunselmeyer Ferreira
Format: Article
Language:English
Published: Cambridge University Press
Series:Parasitology
Subjects:
drug repurposing
Echinococcus granulosus
Echinococcus multilocularis
Mesocestoides corti
Mevalonate pathway
statins
Taenia solium
Online Access:https://www.cambridge.org/core/product/identifier/S0031182024001586/type/journal_article
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