PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma

PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma

Abstract Background Alpha-fetoprotein (AFP) is a key biomarker for hepatocellular carcinoma (HCC), but 30–40% of cases are AFP-negative. Prothrombin induced by vitamin K absence II (PIVKA-II) is more sensitive for HCC detection, though its role in systemic therapy remains underexplored. This study a...

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Bibliographic Details
Main Authors: San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
PIVKA-II
Des-γ-carbonylated prothrombin (DCP)
Alpha-fetoprotein (AFP)
Hepatocellular carcinoma (HCC)
Biomarker
Online Access:https://doi.org/10.1186/s12885-025-13568-4
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https://doi.org/10.1186/s12885-025-13568-4

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