Discovery of Antibodies Against Endemic Coronaviruses with NGS-Based Human Fab Phage Display Platform

Discovery of Antibodies Against Endemic Coronaviruses with NGS-Based Human Fab Phage Display Platform

<b>Background:</b> There is an unmet medical need to develop a vaccine targeting endemic coronaviruses. Antigen-specific monoclonal antibodies (mAbs) are crucial for many assays to support vaccine development. <b>Objective:</b> In this study, we used the HuCal Fab phage displ...

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Bibliographic Details
Main Authors: Oscar Chi-Chien Pan, Sean Miller, Ruchin Patel, Shreya Mukhopadhyay, Giancarlo Sarullo, Gwenny Go, Jennifer Galli, Jamie Hessels, Barbara Schlingmann-Molina, Emmanuel Ndashimye, Zhiyun Wen, Christopher Warren, Eberhard Durr, Lan Zhang, Kalpit A. Vora, Arthur Fridman, Zhifeng Chen
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antibodies
Subjects:
monoclonal antibody
Human Fab phage display
PacBio
next-generation sequencing (NGS)
Online Access:https://www.mdpi.com/2073-4468/14/2/28
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