Isodon lophanthoides alleviates liver fibrosis via modulation of purine metabolism and NF-κB signaling pathway: insights from multi-omics analysis

Isodon lophanthoides alleviates liver fibrosis via modulation of purine metabolism and NF-κB signaling pathway: insights from multi-omics analysis

BackgroundIsodon lophanthoides, a core botanical drug in Yao ethnomedicine, has traditionally been used to treat jaundice-type hepatitis and cholecystitis. However, its therapeutic potential and mechanisms against liver fibrosis remain largely unexplored.MethodsThe metabolites of I. lophanthoides wa...

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Bibliographic Details
Main Authors: Kuikui Chen, Jie Liang, Yong Tan, Yaohua Li, Xiaojiao Pan, Zhonghui Guo, Wentao Zhang, Zongxi Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
Isodon lophanthoides
liver fibrosis
multi-omics
qualitative and quantitative analysis
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1630927/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1630927/full

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