<i>Mammea siamensis</i> Flower Extract-Induced Cell Death Apoptosis in HCT116 Colon Cancer Cells via Vacuolar-Type H<sup>+</sup>-ATPase Inhibition Associated with GSK-3β/β-Catenin, PI3K/Akt/NF-κB, and MAPK Signaling Pathway

<i>Mammea siamensis</i> Flower Extract-Induced Cell Death Apoptosis in HCT116 Colon Cancer Cells via Vacuolar-Type H<sup>+</sup>-ATPase Inhibition Associated with GSK-3β/β-Catenin, PI3K/Akt/NF-κB, and MAPK Signaling Pathway

<b>Background and Objective:</b> <i>Mammea siamensis</i> (MS) is a Thai herb used in traditional medicine. Previous studies have reported the antiproliferative effects of its constituents in various cancer cell lines. However, the effects of MS extract on cytotoxicity and mol...

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Bibliographic Details
Main Authors: Pornnapa Sitthisuk, Watcharaporn Poorahong, Sukanda Innajak, Aungkana Krajarng, Siritron Samosorn, Ramida Watanapokasin
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceuticals
Subjects:
<i>Mammea siamensis</i>
apoptosis
colon cancer
MAPK
PI3K/Akt/NF-κB
GSK-3β/β-catenin
Online Access:https://www.mdpi.com/1424-8247/18/4/441
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