Discovery of potent allosteric antibodies inhibiting EGFR

Discovery of potent allosteric antibodies inhibiting EGFR

In this work, we report the discovery of potent anti-epidermal growth factor receptor (EGFR) allosteric heavy-chain antibodies by combining camelid immunization and fluorescence-activated cell sorting (FACS). After immunization and yeast surface display library construction, allosteric clones were o...

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Bibliographic Details
Main Authors: Léxane Fournier, Lukas Pekar, Birgitta Leuthner, Harald Kolmar, Lars Toleikis, Stefan Becker
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Allostery
antibody discovery
cancer therapy
EGFR
heavy-chain antibody
triple-negative breast cancer
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2406548
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https://www.tandfonline.com/doi/10.1080/19420862.2024.2406548

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