Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

Abstract Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of variants in genes selectively expressed in microglia are associated with an increased risk for neurodegenerative diseases such as Al...

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Main Authors: Julia K Götzl, Matthias Brendel, Georg Werner, Samira Parhizkar, Laura Sebastian Monasor, Gernot Kleinberger, Alessio‐Vittorio Colombo, Maximilian Deussing, Matias Wagner, Juliane Winkelmann, Janine Diehl‐Schmid, Johannes Levin, Katrin Fellerer, Anika Reifschneider, Sebastian Bultmann, Peter Bartenstein, Axel Rominger, Sabina Tahirovic, Scott T Smith, Charlotte Madore, Oleg Butovsky, Anja Capell, Christian Haass
Format: Article
Language:English
Published: Springer Nature 2019-05-01
Series:EMBO Molecular Medicine
Subjects:
disease‐associated and homeostatic microglial signatures
microglia
neurodegeneration
progranulin
TREM2
Online Access:https://doi.org/10.15252/emmm.201809711
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https://doi.org/10.15252/emmm.201809711

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