Engineering of photo-inducible binary interaction tools for biomedical applications
Abstract The ssrA-sspB dimerization system, derived from the bacterial degradation machinery, comprises a 7-residue ssrA peptide and its binding partner sspB. The compact size of ssrA makes it ideal for insertion into proteins of interest to manipulate host protein function by engineered light-respo...
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| Main Authors: | Yi-Tsang Lee, Lei Guo, Tien-Hung Lan, Tatsuki Nonomura, Gan Liu, Guolin Ma, Rui Wang, Yun Huang, Yubin Zhou |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61710-4 |
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