Engineering of photo-inducible binary interaction tools for biomedical applications

Abstract The ssrA-sspB dimerization system, derived from the bacterial degradation machinery, comprises a 7-residue ssrA peptide and its binding partner sspB. The compact size of ssrA makes it ideal for insertion into proteins of interest to manipulate host protein function by engineered light-respo...

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Bibliographic Details
Main Authors: Yi-Tsang Lee, Lei Guo, Tien-Hung Lan, Tatsuki Nonomura, Gan Liu, Guolin Ma, Rui Wang, Yun Huang, Yubin Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61710-4
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