A gold nanoparticle/peptide vaccine designed to induce SARS-CoV-2-specific CD8 T cells: a double-blind, randomized, phase 1 study in Switzerland

A gold nanoparticle/peptide vaccine designed to induce SARS-CoV-2-specific CD8 T cells: a double-blind, randomized, phase 1 study in Switzerland

Abstract Background New vaccines with broader protection against SARS-CoV-2 are needed to reduce the risk of immune escape and provide broad and long-lasting cellular immunity. The objectives of the naNO-COVID trial were to evaluate the safety and immunogenicity of a CD8 + T cell, gold nanoparticle-...

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Main Authors: Juliette Besson, Régine Audran, Maxime Karlen, Alix Miauton, Hélène Maby-El Hajjami, Loane Warpelin-Decrausaz, Loredana Sene, Sylvain Schaufelberger, Vincent Faivre, Mohamed Faouzi, Mary-Anne Hartley, François Spertini, Blaise Genton
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Infectious Diseases
Subjects:
COVID-19
SARS-CoV-2
Vaccine
Nanoparticle
Cellular
Immunity
Online Access:https://doi.org/10.1186/s12879-025-10844-3
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https://doi.org/10.1186/s12879-025-10844-3

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