High-dose IL-37 promotes inflammatory activity of macrophage via Preferential ligation of the IL-18Rα

High-dose IL-37 promotes inflammatory activity of macrophage via Preferential ligation of the IL-18Rα

Abstract Interleukin-37 (IL-37) exists in various human tissues and organs and exhibits extensive anti-inflammatory activity. Recombinant IL-37 ameliorates the insulin resistance and inflammation associated with obesity and type 2 diabetes (T2DM). However, the specific role and underlying mechanisms...

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Bibliographic Details
Main Authors: Yu Zhang, Beixi Shi, Yaxin Bi, Xiaxin Wu, Xiangning Li, Jinfeng Wu, Jiahui Qiu, Zhijie Lin, Guotao Lu, Weijuan Gong
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
IL-37
IL-18Rα
Type 2 diabetes
Macrophage
Inflammation
Online Access:https://doi.org/10.1038/s41598-025-05623-8
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https://doi.org/10.1038/s41598-025-05623-8

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