Convergent evolution of antibiotic resistance mechanisms between pyrrolobenzodiazepines and albicidin in multidrug resistant Klebsiella pneumoniae

Convergent evolution of antibiotic resistance mechanisms between pyrrolobenzodiazepines and albicidin in multidrug resistant Klebsiella pneumoniae

Abstract Pyrrolobenzodiazepines (PBDs) containing C8-linked aliphatic heterocycles have been developed as a new class of potent antibacterial compounds. They are active against multidrug resistant Gram-negative pathogens, including Klebsiella pneumoniae. When isolates were exposed to PBDs, they acqu...

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Main Authors: Yasmin M. Surani, Matthew E. Wand, Pietro Picconi, Michele Di Palma, Riccardo Zenezini Chiozzi, Md. Mahbub Hasan, Paolo Andriollo, Stefan Grätz, Kazi S. Nahar, Michael Maynard-Smith, Roderich D. Süssmuth, Roberto A. Steiner, Khondaker Miraz Rahman, Charlotte K. Hind, J. Mark Sutton
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Antimicrobials and Resistance
Online Access:https://doi.org/10.1038/s44259-025-00104-4
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https://doi.org/10.1038/s44259-025-00104-4

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