Quantitatively defined stromal B cell aggregates are associated with response to checkpoint inhibitors in unresectable melanoma

Quantitatively defined stromal B cell aggregates are associated with response to checkpoint inhibitors in unresectable melanoma

Summary: Multiplex immunofluorescence (mIF) is a promising tool for immunotherapy biomarker discovery in melanoma and other solid tumors. mIF captures detailed phenotypic information of immune cells in the tumor microenvironment, as well as spatial data that can reveal biologically relevant interact...

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Main Authors: James W. Smithy, Xiyu Peng, Fiona D. Ehrich, Andrea P. Moy, Mohammad Yosofvand, Colleen Maher, Nathaniel Aleynick, Rami Vanguri, Mingqiang Zhuang, Jasme Lee, MaryLena Bleile, Yanyun Li, Michael A. Postow, Katherine S. Panageas, Travis J. Hollmann, Margaret K. Callahan, Ronglai Shen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003250
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http://www.sciencedirect.com/science/article/pii/S2211124725003250

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