Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver

Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver

Background & Aims: Hepatocyte-specific deficiency of the phosphatase and tensin homolog (PTEN) triggers steatosis and the development of hepatic tumors. The hepatoprotective effect of PTEN may partly depend on its ability to block insulin receptor (IR) and insulin-like growth factor 1 recept...

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Main Authors: Monika Gjorgjieva, Nicolas Calo, Cyril Sobolewski, Dorothea Portius, Jean-Luc Pitetti, Flavien Berthou, Anne-Sophie Ay, Marion Peyrou, Lucie Bourgoin, Christine Maeder, Margot Fournier, Marta Correia de Sousa, Etienne Delangre, Laurent Vinet, Xavier Montet, Christine Sempoux, Serge Nef, Michelangelo Foti
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:JHEP Reports
Subjects:
Hepatic metabolism
Hepatocarcinogenesis
Insulin receptor
IGF-1 receptor
Steatosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924003094
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