An LC-MS Method to Quantify Rhein and Its Metabolites in Plasma: Application to a Pharmacokinetic Study in Rats

An LC-MS Method to Quantify Rhein and Its Metabolites in Plasma: Application to a Pharmacokinetic Study in Rats

<b>Background:</b> Diacerein, a prodrug of Rhein, is commonly prescribed for the management of joint disorders, specifically osteoarthritis. This study aimed to develop and validate an LC-MS/MS method to quantify Rhein and its major metabolites, Rhein-G1 and Rhein-G2, in plasma samples....

Full description

Saved in:
Bibliographic Details
Main Authors: Nyma Siddiqui, Yuan Chen, Ting Du, Yang Wang, Charmeyce Buck, Song Gao
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Metabolites
Subjects:
LC-MS
diacerein
Rhein
Rhein-glucuronides
PK
Online Access:https://www.mdpi.com/2218-1989/15/6/407
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2218-1989/15/6/407

Similar Items