<i>MYBPC3</i> D389V Variant Induces Hypercontractility in Cardiac Organoids

<i>MYBPC3</i> D389V Variant Induces Hypercontractility in Cardiac Organoids

<i>MYBPC3</i>, encoding cardiac myosin binding protein-C (cMyBP-C), is the most mutated gene known to cause hypertrophic cardiomyopathy (HCM). However, since little is known about the underlying etiology, additional in vitro studies are crucial to defining the underlying molecular mechan...

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Main Authors: Darshini Desai, Taejeong Song, Rohit R. Singh, Akhil Baby, James McNamara, Lisa C. Green, Pooneh Nabavizadeh, Mark Ericksen, Sholeh Bazrafshan, Sankar Natesan, Sakthivel Sadayappan
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
hypertrophic cardiomyopathy
hypercontraction
MYBPC3
cardiac organoids
mavacamten
Online Access:https://www.mdpi.com/2073-4409/13/22/1913
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