Extracellular matrix stiffness: mechanisms in tumor progression and therapeutic potential in cancer

Abstract Tumor microenvironment (TME) is a complex ecosystem composed of both cellular and non-cellular components that surround tumor tissue. The extracellular matrix (ECM) is a key component of the TME, performing multiple essential functions by providing mechanical support, shaping the TME, regul...

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Bibliographic Details
Main Authors: Meiling Zhang, Bin Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Experimental Hematology & Oncology
Subjects:
Online Access:https://doi.org/10.1186/s40164-025-00647-2
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