Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4+ T cells in head and neck cancer

Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4+ T cells in head and neck cancer

Abstract Tumor tertiary lymphoid structures (TLS), especially mature TLS (mTLS), have been associated with better prognosis and improved responses to immune checkpoint blockade (ICB), but the underlying mechanisms remain incompletely understood. Here, by performing single-cell RNA, antigen receptor...

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Main Authors: Hao Li, Meng-Jie Zhang, Boxin Zhang, Wen-Ping Lin, Shu-Jin Li, Dian Xiong, Qing Wang, Wen-Da Wang, Qi-Chao Yang, Cong-Fa Huang, Wei-Wei Deng, Zhi-Jun Sun
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59341-w
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https://doi.org/10.1038/s41467-025-59341-w

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