A modular click ligand-directed approach to label endogenous dopamine D1 receptors in live cells

A modular click ligand-directed approach to label endogenous dopamine D1 receptors in live cells

Abstract Most luminescence-based technologies to determine the pharmacological properties of G Protein-Coupled Receptors (GPCRs) rely on the overexpression of genetically modified receptors. However, it is essential to develop approaches allowing the specific labelling of native receptors. Here we r...

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Main Authors: Xavier Gómez-Santacana, Marin Boutonnet, Carles Martínez-Juvés, Marta Cimadevila, Juanlo Catena, Enora Moutin, Thomas Roux, Eric Trinquet, Laurent Lamarque, Julie Perroy, Laurent Prézeau, Jurriaan M. Zwier, Jean-Philippe Pin, Amadeu Llebaria
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01504-3
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https://doi.org/10.1038/s42004-025-01504-3

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