The Effects of Perinatal Phencyclidine Administration on the Density and Branching of Astrocytes in the Brain of Aged Rats

The Effects of Perinatal Phencyclidine Administration on the Density and Branching of Astrocytes in the Brain of Aged Rats

Phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate glutamate receptor (NMDA-R), is used for modeling schizophrenia in animals, as NMDA-R hypofunction is vital in its pathophysiology. Recent studies have shown that glial fibrillary acidic protein (GFAP), an astrocyte marker, is altered in...

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Main Authors: Ivaz Sava, Puškaš Nela, Paunović Bojana, Stojković Tihomir, Nikolić Tatjana, Bogosavljević Milica Velimirović, Živković Milica, Petronijević Nataša
Format: Article
Language:English
Published: Sciendo 2025-06-01
Series:Acta Veterinaria
Subjects:
ageing
astrocytes
glial fibrillary acidic protein – gfap
phencyclidine
schizophrenia
Online Access:https://doi.org/10.2478/acve-2025-0014
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https://doi.org/10.2478/acve-2025-0014

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