Computational Design and Evaluation of Peptides to Target SARS-CoV-2 Spike–ACE2 Interaction

Computational Design and Evaluation of Peptides to Target SARS-CoV-2 Spike–ACE2 Interaction

The receptor-binding domain (RBD) of SARS-CoV-2 spike protein is responsible for the recognition of the Angiotensin-Converting Enzyme 2 (ACE2) receptor in human cells and, thus, plays a critical role in viral infection. The therapeutic value of targeting this interaction has been proven by a sizable...

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Main Authors: Saja Almabhouh, Erika Cecon, Florence Basubas, Ruben Molina-Fernandez, Tomasz Maciej Stepniewski, Jana Selent, Ralf Jockers, Amal Rahmeh, Baldo Oliva, Narcis Fernandez-Fuentes
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
peptide design
SARS-CoV-2
spike protein
ACE2 receptor
molecular dynamics
time-resolved FRET assay
Online Access:https://www.mdpi.com/1420-3049/30/8/1750
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