Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity

Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity

Despite tyrosine sulfation being a relatively common post-translational modification (PTM) on the secreted proteins of higher eukaryotic organisms, there have been surprisingly few reports of this modification occurring in recombinant monoclonal antibodies (mAbs) expressed by mammalian cell lines an...

Full description

Saved in:
Bibliographic Details
Main Authors: Christopher B. Lietz, Ekaterina Deyanova, Younhee Cho, Jon Cordia, Sarah Franc, Sally Kabro, Steven Wang, David Mikolon, Douglas D. Banks
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Biotherapeutic
mass spectrometry
monoclonal antibody
peptide map
post-translational modification
sulfotyrosine
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2259289
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2259289

Similar Items